ABSTRACT
Objective To evaluate the clinical value of oxidative stress related indicators in chronic kidney disease (CKD)diagnosis.Methods A total of 220 CKD patients in different stages and 100 healthy persons were enrolled.The serum levels of Creatinine (Cr), uric acid (UA),γ-glutamyl transpeptidase (GGT) and homocysteine (HCY) were measured.CKD patients were divided into 5 stages according to the calculated estimated glomerular filtration rate (eGFR).CKD patients in stage 1, 2 were incorporated as group CDKⅠand incorporating CKD patients in stage 3, 4, 5 patients were incorporated as group CDKⅡ.T test was used to compare the difference of UA, GGT, HCY levels between healthy people and CKD patients.Receiver operating characteristic (ROC) curve was used to evaluate the clinical value of each index in CKD diagnosis.Z test was used to compare the difference of the area under curve (AUC) of UA, GGT, HCY and combined detection.Results The mean levels of serum UA, GGT, HCY between CKD patients and healthy person were statistically significant (P<0.05).In healthy persons and CKD patients study, the AUC of UA, GGT, HCY and combined detection were 0.823, 0.585, 0.850 and 0.924, respectively.The AUC of combined detection was significantly higher than single detection (P<0.05).In group CDKⅠ andⅡ study, the AUC of UA, GGT, HCY and combined detection were 0.719, 0.485, 0.828 and 0.834, respectively.The AUC of combined detection was not significantly higher than HCY detection (P>0.05).Conclusion Combined detection of oxidative stress related index has high application value in CKD early diagnosis.